Instead of being icons of the ideal

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steroids It is also hard to treat NP effectively. The molecular mechanisms underlying pain and NP in OA are still not well understood and therefore require further study. The high prevalence of OA means research in this field has the potential to impact many individuals.Objectives: The aims of this thesis were a) to describe the effects of NP on post TJR satisfaction, b) to investigate the genetic contribution to NP in people post TJR using a genome wide approach and c) to analyse two candidate genes for an association with pain in people with symptomatic OA or asymptomatic OA.Methods: Individuals from three independent Nottinghamshire based cohorts were analysed: 1) the Genetics of OA and Lifestyle (GOAL) study, 2) the Nottingham Genetics of OA Study (NGOAS) and 3) individuals recruited from Nottinghamshire who formed part of the Arthritis Research Council OA Genetics (arcOGEN) Consortium steroids.


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